Effects of intravenously administered human atrial natriuretic peptide on elevated blood pressure during surgery

Abstract  The effect of human atrial natriuretic peptide (hANP) on blood pressure (Bp) was evaluated in 11 patients who had elevated systoric Bp of over 150mmHg during surgery. A bolus injection of 50µg or 100µg of hANP decreased Bp with an immediate response by 27.6 ± 3.1mmHg (P < 0.001) or 40.7 ± 4.2mmHg (P < 0.001), respectively, accompanying with tremendously increased urine output. Heart rate and PaO 2 were not altered. Thus, a intravenous bolus injection of hANP is an useful therapeutic tool for the treatment of acutely elevated Bp during anesthesia.(Iwatsuki N, Katoh M, Yasuda A et al.: Effect of intravenously administered human atrial natriuretic peptide on elevated blood pressure during surgery. J Anesth 3: 218–222, 1989)